Forskolin

Posted by Babara Giordano on

Forskolin (coleonol) is a labdane diterpene that is produced by the Indian Coleus plant (Plectranthus barbatus). Forskolin is commonly used as a tool in biochemistry to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP. cAMP is an important second messenger necessary for the proper biological response of cells to hormones and other extracellular signals. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones. Cyclic AMP acts by activating cAMP-sensitive pathways such as protein kinase A and Epac.

 

Why Is Forskolin the Hottest Diet Today For Both Men & Women?

A few years ago, no one ever heard of forskolin. Now, Forskolin is the new leader in the diet world.

In a recent study published in the Obesity journal, scientists used 500mg of Forskolin to research its effect on the body. The clinical study supports the positive effect that Forskolin has on the body. 

It's important to note that only a 100% pure Coleus Forskohlii extract was used in the study (exactly as found in MIT Nutrition Forskolin), not a synthetic extract grown in the lab. MIT Nutrition Forskolin only contains the purest ingredients, with no added fillers, binders or artificial chemicals.

*Results contained within may not be an implication of future results. Always consult your physician before making any dietary changes or starting any nutrition, health control or exercise program.

Don't Get Fooled When Buying Forskolin!

There is a lot to watch out for when buying Forskolin supplements. For your convenience, we summarized the most important factors to look out for. You can see what the recommendations are and where our product stands compared to others on the market. The world's most famous Doctor gives very specific criteria on what to look for.

Is the Forskolin standardized to 40%? Forskolin extracts with a standard lower than 40% will not be as effective*.

Make sure you are taking optimal 600mg daily dose to help you reach your goals.

Here are the criteria:

  • It must contain 40% Forskolin.
  • It must have no fillers, binders or any additives.
  • It must be 100% pure and packaged in a vegetarian capsule.
  • You must take at least 600mg a day (300mg capsules, taken 2 times a day).

Always check the label to make sure it meets all of these criteria. If it doesn't, don't buy it!

Here are more factors to look out for when searching for Forskolin supplements:

  • Look out for false claims and unsupported facts.
  • Make sure the supplement is made in an approved registered laboratory.
  • Make sure the manufacturing facility is cGMP certified.
  • And finally, make sure it complies with the US Pharmaceutical quality standards.

YES, MIT Nutrition Forskolin meets all the above Criteria: It does not contain fillers, binders or any additives and has a serving size of 600 mg daily. It is manufactured at approved registered and cGMP certified lab, which complies with US Food Supplements quality standards.

Biosynthesis

  • As with other members of the large diterpene family of natural products, forskolin is derived from geranylgeranyl pyrophosphate (GGPP). Forskolin, however, contains some unique functional elements, key among them is the presence of a tetrahydropyran derived heterocyclic ring. This ring is synthesized after the formation of the trans-fused carbon ring systems are formed by a carbocation mediated cyclization. The remaining tertiary carbocation is quenched by a molecule of water. After deprotonation, the remaining hydroxyl group is free to form the heterocyclic ring. This cyclization can occur either by attack of the alcohol oxygen onto the allylic carbocation formed by loss of diphosphate, or by an analogous SN2' like displacement of the diphosphate. This forms the core ring system A of forskolin.
  • The remaining modifications of the core ring system A can putatively be understood as a series of oxidation reactions to form a poly-ol B which is then further oxidized and esterified to form the ketone and acetate ester moieties seen in forskolin. However, because the biosynthetic gene cluster has not been described, this putative synthesis could be incorrect in the sequence of oxidation/esterification events, which could occur in almost any order.

Safety in pregnancy

There is limited information on Forskolin use in pregnant women. The safety has not yet been determined.Forskolin should be used with caution or avoided altogether in women who are pregnant.

 

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